REGENERATIVE GYNAECOLOGY & INFERTILITY
Focuses on treatments and technologies that help both men and women to get biological child with the help of Stem Cell and Regenerative Medicine
PRP-therapy (autologous platelet-rich plasma)
It is the treatment with own blood plasma enriched with platelets – blood cells containing many alpha-granules with a large number of growth factors. Growth factors play a key role in tissue regeneration, activate cell growth and their renewal. When high concentrated platelet-derived factors are injected into the damaged or atrophied tissues, tissues healing and regeneration processes are activated.
How can PRP-therapy help with infertility treatment?
For women, it’s an opportunity to rule the biological clock!The main indications for PRP-therapy:
Premature Ovarian Failure – PRP-therapy helps for ovarian rejuvenation and makes it possible to restart menstrual cycle. Women of advanced maternal age (menopausal and perimenopausal women) – PRP-therapy can help to grow more eggs, which will increase the chances for a positive result in the IVF cycle or for spontaneous pregnancy. Patients with endometrial hypoplasia – successful embryo implantation is impossible for them due to a thin layer of the endometrium.
PRP-therapy for such women is a real breakthrough, especially in cases when it is not possible to grow endometrium with the help of medicines. In cases like chronic endometritis and endometriosis of the uterus, Asherman’s syndrome, Recurrent failed IVF cycles, Complications after unsuccessful surgical treatment, Complications after abortions, PRP-therapy significantly improves embryo implantation in both IVF cycles and natural pregnancy. For men, it’s an opportunity to become a biological father!
PRP-therapy of the testicles is carried out in the most complicated cases of infertility: There are very few spermatozoa in the sperm (oligozoospermia <10 million / ml).
Usually, in such cases, the chances for pregnancy are very small. But we can offer a new innovative treatment – using PRP-therapy of the testicles! The purpose of the procedure is to activate spermatogenesis (sperm production) in the testicles, which is not active enough, that’s why sperm quality is reduced and pregnancy in the partner does not appear.
When high concentrated platelet-derived factors are injected into the testicular tissues, cell healing and regeneration processes are activated, which supports to the restoration of spermatogenesis. This procedure is innovative and, due to its recent appearance, still experimental. However, according to currently available data, it succeeds in about 50-60% of cases. In any case, advanced medicine specialists believe this is a breakthrough in reproductive technologies that could potentially give a chance for pregnancy with their own eggs – or for the restoration and activation of spermatogenesis in men and the opportunity to have their own children in a seemingly hopeless situation.
Ovarian Rejuvenation with BMAC Cellular Therapy :
Menopausal or perimenopausal women under the age of 45 years, infertile women, who are over the age of 35 years, having low egg reserve and low AntiMullerian Hormone levels (AMH), women under the age of 35 years, who have low egg reserve and low AntiMullerian Hormone levels, and women with premature ovarian failure (POF).
BMAC (Bone Marrow Aspirated Concentrates):
It is a natural product where a high level of platelets is concentrated and CD34+ cells as well as mononuclear cells but with growth factors concentration 4 to 5 times greater than plasma. Growth factors are stored in granules and include platelet derivate growth factor (PDGFs), Transforming growth factor-beta (TGF-β), vessel endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), e insulin growth factor (IGF), and some others. These cytokines play an important role in cellular proliferation, chemotaxis, and differentiation of mesenchymal and other cells and promote angiogenesis. The protocol for ovarian rejuvenation includes two steps. The first is the preparation of the Bone marrow concentrate. This begins by drawing bone marrow from the ileac crest for the woman and then isolate with specific techniques including centrifugation and concentrate of the BMA. The second part is the injection of the BMAC to the two ovaries by laparoscopy. Our holistic program followed by BMAC cellular therapy additionally provides BHRT, Personalised Supplementations and genomic diets. Then AMH (anti-Mullerian hormone), FSH, LH and Estradiol levels are measured at monthly intervals in women who do not menstruate, and during the menstrual flow in menstruating women for a period of six months. If the AMH levels rise, while the FSH, LH, and estradiol levels become lower, there is objective evidence of ovarian rejuvenation is demonstrated.